Fabrication of chondrocytes/chondrocyte-microtissues laden fibrin gel auricular scaffold for microtia reconstruction. Haiqiong Yue, Janak L Pathak, Rui Zou, Lei Qin, Ting Liao, Yongxin Hu, Wei Kuang, Libin Zhou.An interpenetrating polymer network hydrogel with biodegradability through controlling self-assembling peptide behavior with hydrolyzable cross-linking networks. Recent Progress on Cellulose‐Based Ionic Compounds for Biomaterials. Yang Yang, Yi‐Tung Lu, Kui Zeng, Thomas Heinze, Thomas Groth, Kai Zhang.Response to Letter to Editor “Comment on ‘A photo-crosslinkable cartilage-derived extracellular matrix bioink for auricular cartilage tissue engineering’ by Visscher et al.”.
Human-engineered auricular reconstruction (hEAR) by 3D-printed molding with human-derived auricular and costal chondrocytes and adipose-derived mesenchymal stem cells.
The Journal of Physical Chemistry C 2016, 120 Molecular Level Understanding of Biological Systems with High Motional Heterogeneity in Its Absolute Native State. Purusottam, Akhila Viswan, and Neeraj Sinha. Interpenetrating Polymer Network Hydrogels via a One-Pot and in Situ Gelation System Based on Peptide Self-Assembly and Orthogonal Cross-Linking for Tissue Regeneration. Shohei Ishikawa, Kazutoshi Iijima, Daisuke Matsukuma, Yukiyo Asawa, Kazuto Hoshi, Shigehito Osawa, Hidenori Otsuka.This article is cited by 48 publications. This study shows that engineered cartilage tissues are able to serve as a shell that entirely covers the medical implant, which may minimize the morbidity associated with implant dislodgement. An initial cell density was determined that is critical for the production of matrix components such as glycosaminoglycans (GAG), elastin, type II collagen, and for mechanical strength. Histomorphological evaluations consistently showed cartilage formation over the medical implants with the maintenance of dimensional stability. After implantation, the retrieved engineered cartilage tissue was evaluated by histo- and immunohistochemical, biochemical, and mechanical analyses. To demonstrate the in vivo stability of cell−fibrin constructs, we tested variations of fibrinogen and thrombin concentration as well as cell density. This study investigated whether cartilage tissue, engineered with chondrocytes and a fibrin hydrogel, would provide adequate coverage of a commercially used medical implant. To overcome these limitations, we propose a system in which tissue-engineered cartilage serves as a shell that entirely covers the alloplastic implants. However, the use of these implants is often associated with complications, including inflammation, infection, erosion, and dislodgement. Currently, alloplastic ear-shaped medical implants composed of silicon and polyethylene are being used clinically. Cartilage tissues are often required for auricular tissue reconstruction.
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